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Literature

The results of the work on 2-IB is published in the following peer-reviewed journals:

  • Peeters-Scholte C, Meilin S, Berckovich Y, Westers P. 2-iminobiotin, a selective inhibitor of nitric oxide synthase, improves memory and learning in a rat model after four vessel occlusion, mimicking cardiac arrest. PLoS One. 2023 Sep 25;18(9):e0291915. doi: 10.1371/journal.pone.0291915. PMID: 37747911; PMCID: PMC10519591. link

  • Admiraal MM, Velseboer DC, Tjabbes H, Vis P, Peeters-Scholte C, Horn J. Neuroprotection after cardiac arrest with 2-iminobiotin: a single center phase IIa study on safety, tolerability, and pharmacokinetics. Front Neurol. 2023 Jun 2;14:1136046. doi: 10.3389/fneur.2023.1136046. PMID: 37332991; PMCID: PMC10272808. link

  • Biselele T, Bambi J, Betukumesu DM, Ndiyo Y, Tabu G, Kapinga J, Bola V, Makaya P, Tjabbes H, Vis P, Peeters-Scholte C. A Phase IIa Clinical Trial of 2-Iminobiotin for the Treatment of Birth Asphyxia in DR Congo, a Low-Income Country. Paediatr Drugs. 2020 Feb;22(1):95-104. doi: 10.1007/s40272-019-00373-3. 

  • Favié LMA, Peeters-Scholte CMPCD, Bakker A, Tjabbes H, Egberts TCG, van Bel F, Rademaker CMA, Vis P, Groenendaal F. Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia. Pediatr Res. 2020 Mar;87(4):689-696. doi: 10.1038/s41390-019-0587-1.link.  

  • Favié LMA, Peeters-Scholte CMPCD, Bakker A, Tjabbes H, Egberts TCG, van Bel F, Rademaker CMA, Vis P, Groenendaal F. Translation from animal to clinical studies, choosing the optimal moment. Pediatr Res. 2020 Dec;88(6):836-837. doi: 10.1038/s41390-020-0820-y. 

  • van Hoogdalem EJ, Peeters-Scholte CMPCD, Leufkens PWTJ, Hartstra J, van Lier JJ, de Leede LGJ. First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects. Curr Clin Pharmacol. 2020;15(2):152-163. doi: 10.2174/1574884714666191017111109.

  • Albrecht M, Zitta K, Groenendaal F, Bel van F, Peeters-Scholte C. Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS. Free Radic. Biol. Med. 2019:142:123-131.doi: 10.1016/j.freeradbiomed.2019.02.025. For more information see following link

  • Favié L, Cox A, Hoogen van den A., Nijboer C, Peeters-Scholte C, Bel van F, Egberts T, Rademaker C, Groenendaal F. Nitric oxide synthase inhibition as a neuroprotective strategy following hypoxic-ischemic encephalopathy evidence from animal studies. Frontier in Neurology. 2018:9:258. doi: 10.3389/fneur.2018.00258. For more information see following link

  • Zitta K, Peeters-Scholte C, Sommer L, Gruenewald M, Hummitzsch Lars, Parczany K, Steinfath M, Albrecht M. 2-Iminobiotin superimposed on hypothermia protects human neuronal cells from hypoxia-induced cell damage: An in-vitro study. Front. Pharmacol.  2018:8:971. doi: 10.3389/fphar.2017.00971. For more information see following link 

  • Zitta K, Peeters-Scholte C, Sommer L, Parczany K, Steinfath M, Albrecht M. Insights into the neuroprotective mechanisms of 2-iminobiotin employing an in-vitro model of hypoxic-ischemic cell injury. Eur J Pharmacol. 2016;792:63-69. doi:10.1016/ j.ejphar.2016.10.026

  • Bjorkman ST, Ireland Z, Fan X, van der Wal WM, Roes KC, Colditz PB, Peeters-Scholte CM. Short-term dose-response characteristics of 2-iminobiotin immediately postinsult in the neonatal piglet after hypoxia-ischemia. Stroke. 2013;44:809-11. doi:10.1161/STROKEAHA.112.677922.

  • Neurophyxia B. V. Determination of target dose for Phase ii study of 2Iminobiotin (2-IB) in neonates with perinatal asphyxia/2012-01-18-Determination-of-target-dose-for-Phase-ii.pdf (2012). For more information see following link 

  • Phase 1 clinical study: First-in-man 2-IB dose escalation study. For more information see following link

  • Fan X, Kavelaars A, Heijnen CJ, Groenendaal F, van Bel F. Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. Curr Neuropharmacol. 2010:8:324-34. doi:10.2174/157015910793358150.

  • Neurophyxia B.V. Extract Pharmacology Data Report on compound 2-Iminobiotin. For more information see following link
  • Fan X, van Bel F. Pharmacological neuroprotection after perinatal asphyxia. J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:17-9.

  • Van Dijk AJ, Jonker FH, Taverne MAM. The effect of administration of 2-iminobiotin at birth on growth rates, morbidity and mortality in piglets under farm conditions. Livestock Science 2007. Livestock Science 2008; 115;129-136. doi.org/10.1016/j.livsci.2007.06.016

  • Nijboer CH, Kavelaars A, van Bel F, Heijnen CJ, Groenendaal F. Gender-dependent pathways of hypoxiaischemia- induced cell death and neuroprotection in the immature P3 rat. Dev Neurosci 2007;29:385-92. doi: 10.1159/000105479.

  • Nijboer CH, Groenendaal F, Kavelaars A, Hagberg HH, van Bel F, Heijnen CJ. Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway. J Cereb Blood Flow Metab. 2007;272:282-92. doi:10.1038/sj.jcbfm.9600342.

  • Van den Tweel ER, van Bel F, Kavelaars A, Peeters-Scholte CM, Haumann J, Nijboer CH, Heijnen CJ, Groenendaal F. Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats. J Cereb Blood Flow Metab. 2005;251:67-74.

  • Peeters-Scholte C, van den Tweel E, Groenendaal F, van Bel F. Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig. Exp Brain Res. 2004;1561:20-6. 

  • Zhu C, Wang X, Qiu L, Peeters-Scholte C, Hagberg H, Blomgren K. Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia. J Neurochem. 2004;90:462-71.

  • Peeters-Scholte C, van den Tweel E, Ioroi T, Post I, Braun K, Veldhuis W,Nicolay K, Groenendaal F, van Bel F. Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective. Exp Brain Res. 2002;147:200-8. 

  • Peeters-Scholte C, Koster J, Van den Tweel E, Blomgren K, Hamers N. Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxiaischemia. Dev Neurosci 2002;24:396-404. 

  • Peeters-Scholte C, Koster J, Veldhuis W, Van den Tweel E, Zhu C et al. Neuroprotection by selective NOS inhibition at 24h after perinatal hypoxia-ischemia. Stroke 2002;33:2304-2310.

  • Peeters-Scholte C. Van den Tweel E, Ioroi T, Post I, Braun K et al. Pharmacological interventions in the newborn piglet in the first 24h after hypoxia ischemia. Exp Brain Res 2002;147:200-208. 

    Other literature on 2-iminobiotin with regard to perinatal asphyxia: 

  • Cerio FG, Lara-Celador I, Alvarez A, Hilario E. Neuroprotective therapies after perinatal hypoxic-ischemic brain injury. Brain Sci. 2013;3:191-214. 

  • Buonocore G, Perrone S, Turrisi G, Kramer BW, Balduini W. New pharmacological approaches in infants with hypoxic-ischemic encephalopathy. Curr Pharm Des. 2012;18(21):3086-100.

  • The effect of administration of 2-iminobiotin at birth on growth rates, morbidity and mortality in piglets under farm conditions. Dijk van AJ, Jonker FH, Taverne MAM. Livestock Science 115; (2008) 129–136.

  • Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351:1985-95. 

  • Sup SJ, Gordon Green B, Grant SK. 2-Iminobiotin is an inhibitor of nitric oxide synthases. BBRC 1994:204:962-8.